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KMID : 1094020120290030233
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Journal of Veterinary Clinics
2012 Volume.29 No. 3 p.233 ~ p.236
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Bioequivalence Evaluation of Two Cefquinome 2.5% Injectable Products in Piglets
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Song In-Bae
Kim Tae-Won
Lee Hong-Gee
Park Byung-Kwon
Yun Hyo-In
Kim Myoung-Seok
Hwang Youn-Hwan
Lim Jong-Hwan
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Abstract
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Cefquinome, a fourth generation cephalosporin, has been solely used for veterinary medicine and has a broad antibacterial spectrum against gram-negatives and gram-positives being very stable to β-lactamases. This study was conducted to evaluate the bioequivalence of two cefquinome 2.5% products in piglets. Plasma cefquinome concentrations were analyzed by liquid chromatography-mass spectrometry (LC/MS). Mean maximum concentration (Cmax) of test product (Cequusⓡ) and reference product (Cobactanⓡ) were 4.34±0.58 and 4.22±0.47 μg/mL, and mean area under the concentration time curve (AUC0→∞) values were 10.43±1.96 and 10.25±2.98 μg?h/mL, respectively. The 90% confidence intervals for the ratio of Cmax (0.941-1.115), and AUC0-∞ (0.927-1.172) values for the test and reference products were within the acceptable bioequivalence limit of 0.80-1.25. It is concluded that two commercial cefquinome injectable solutions are bioequivalent in their extent of drug absorption in piglets.
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KEYWORD
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bioequivalence, cefquinome, LC/MS, pharmacokinetic
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